Advances in Adrenergic Receptor Biology by Qin Wang

By Qin Wang

This quantity of present themes in Membranes specializes in Adrenergic Receptor Biology, starting with a evaluate of earlier successes and historic views then additional discussing present common traits in adrenic receptor reports in a number of contexts. This booklet additionally comprises discussions of the function and dating of adrenergic receptors to various platforms and illnesses, developing Adrenergic Receptor Biology as a wanted, functional reference for researchers.

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J. (2007). Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol Sci, 28, 416–422. , & Limbird, L. E. (2007). Regulation of alpha2AR trafficking and signaling by interacting proteins. Biochem Pharmacol, 73, 1135–1145. , Brady, A. , Allen, P. , & Lefkowitz, R. , (2004). Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science, 304, 1940–1944. Whalen, E. , & Lefkowitz, R. J. (2011). Therapeutic potential of b-arrestin- and G protein-biased agonists.

All of the transcriptional events mediated by bAR stimulation in isolated cardiac nuclei were sensitive to inhibitors of ERK1/2, p38, and JNK as well as PKB. , 2011). Perhaps most interesting was the fact that inhibition of PKB switched isoproterenol from an agonist to an inverse agonist with respect to transcriptional initiation. To date, most studies evaluating the signaling downstream of nuclear GPCRs have relied obviously on isolated nuclei. As can be seen in Figure 3, there are two possible orientations for nuclear GPCRs, one with the receptor C-terminus facing the nucleoplasm and the other facing the cytosol.

For example, b3AR activation of p38 occurs only in adipocytes (Cao, Medvedev, Daniel, & Collins, 2001). For simplicity, receptors are represented as monomers. However, as described in the text, receptor heterodimerization may alter this picture substantially. 2. Organizational Complexity of b-adrenergic Receptor Signaling Systems 23 Hutchinson, & Summers, 2010), presumably not simply to provide an inhibitory stimulus to the same effector enzyme, AC. Since then, it has become clear that each receptor interacts with a wide array of signaling pathways (Fig.

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